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  • 阅读: 2022/7/7 14:30:58

    Journal of Clinical and Translational Hepatology

    2022628

    Volume 10 Issue 3

    10 3 正式出版

    封面文章

    Diagram of novel MT targeted therapeutics in HBV infection

    新型 MT 靶向治疗 HBV 感染示意图

    封面解读

    Numbers indicated putative drug targets.

    (1) MAP1S inhibition/silencing,

    (2) MAP1S-dependent acetylation of MTs, and

    (3) MAP1S dependent autophagy. Blue lines indicate induction. Red lines indicate uppression. A red X indicates inhibition or silencing of MAP1S. Orange/yellow stars represent acetylation of MTs. HBV complete virion is shown by hexagonal capsid with green HBsAg and HBV naked capsid is shown by a brown hexagon.

    HBV, Hepatitis B virus; MAPs, microtubule associated proteins; MTs, microtubules; HCC, hepatocellular carcinoma.

    数字表示推定的药物目标。

    (1) MAP1S 抑制/沉默,

    (2) MTs MAP1S 依赖性乙酰化,和

    (3) MAP1S 依赖性自噬。蓝线表示感应。红线表示压制。红色 X 表示 MAP1S 的抑制或沉默。橙色/黄色星星代表 MTs 的乙酰化。 HBV 完整病毒体由带有绿色 HBsAg 的六角形衣壳显示,而 HBV 裸衣壳由棕色六角形显示。

    HBV、乙型肝炎病毒; MAPs,微管相关蛋白; MTs,微管; HCC,肝细胞癌。

    Contents | 内容概览

    本期共发表22篇文章:包括1Editorial1Hot Topic Commentary13Original Article6Review Article1Case Report

    Editorial

    Unraveling the Dynamic Role of Microtubules in the HBV Life Cycle

    Urania Georgopoulou, John Koskinas

    Doi: 10.14218/JCTH.2022.00135

    Hot Topic Commentary

    Acute Severe Hepatitis of Unknown Origin in Children Across the World: A 2022 Source of Concern

    Lampros Chrysavgis, Evangelos Cholongitas

    Doi: 10.14218/JCTH.2022.00252

    Original Article

    Change of Cytokines in Chronic Hepatitis B Patients and HBeAg are Positively Correlated with HBV RNA, Based on Real-world Study

    Qiqi Zhang, Hui Huang, Aijun Sun, Chunyan Liu, Zhidong Wang, Feifan Shi, Wei Duan, Xueying Sun, Qi Wang, Ping Sun, Chunwen Pu, Yong Zhang

    Doi: 10.14218/JCTH.2021.00160

    Original Article

    Racial and Health Disparities among Cirrhosis-related Hospitalizations in the USA

    Ashwani K. Singal, Yong-Fang Kuo, Juan P. Arab, Ramon Bataller

    Doi: 10.14218/JCTH.2021.00227

    Original Article

    Clinical Predictors of Functional Cure in Children 1–6 Years-old with Chronic Hepatitis B

    Jing Pan, Haiyan Wang, Tiantian Yao, Xuejiao Liao, Hao Cheng, Suthat Liangpunsakul, Yan Wang, Min Zhang, Zheng Zhang

    Doi: 10.14218/JCTH.2021.00142

    Original Article

    Advantages of a Novel Model for Predicting Hepatic Fibrosis in Chronic Hepatitis B Virus Carriers Compared with APRI and FIB-4 Scores

    Na-Ling Kang, Qing-Fa Ruan, De-Sheng Zhang, Xue-Ping Yu, Zhen-Ting Hu, Zhi-Min Lin, Lu-Ying Wu, Meng-Xin Lin, Zu-Xiong Huang, Jia-Ji Jiang, Yu-Rui Liu, Ri-Cheng Mao, Da-Wu Zeng

    Doi: 10.14218/JCTH.2022.00098

    Original Article

    Impact of National Centralized Drug Procurement Policy on Antiviral Utilization and Expenditure for Hepatitis B in China

    Xinyu Zhao, Min Li, Hao Wang, Xiaoqian Xu, Xiaoning Wu, Yameng Sun, Canjian Ning, Bingqiong Wang, Shuyan Chen, Hong You, Jidong Jia, Yuanyuan Kong

    Doi: 10.14218/JCTH.2022.00167

    Original Article

    Dermcidin Enhances the Migration, Invasion, and Metastasis of Hepatocellular Carcinoma Cells In Vitro and In Vivo

    Fanghua Qiu, Huajing Long, Lu Zhang, Jieyuan Liu, Zetian Yang, Xianzhang Huang

    Doi: 10.14218/JCTH.2021.00108

    Original Article

    PNPLA3 rs738409 C>G Variant Influences the Association Between Visceral Fat and Significant Fibrosis in Biopsy-proven Nonalcoholic Fatty Liver Disease

    Gang Li, Liang-Jie Tang, Pei-Wu Zhu, Ou-Yang Huang, Rafael S. Rios, Kenneth I. Zheng, Sui-Dan Chen, Hong-Lei Ma, Giovanni Targher, Christopher D. Byrne, Xiao-Yan Pan, Ming-Hua Zheng

    Doi: 10.14218/JCTH.2021.00286

    Original Article

    Relationship between the Level of Serum Golgi Protein 73 and the Risk of Short-term Death in Patients with ALD-ACLF

    Jingjing Tong, Mingjie Yao, Xiuying Mu, Leijie Wang, Xiajie Wen, Xingran Zhai, Xiang Xu, Yu Wang, Jing Chen, Xiangwei Zhai, Chongdan Guan, Fengmin Lu, Jinhua Hu

    Doi: 10.14218/JCTH.2020.00133

    Original Article

    Development and Validation of a Nomogram for 90-day Outcome in Patients with Hepatitis B Virus-related Acute-on-chronic Liver Failure

    Jun Yang, Ran Xue, Jing Wu, Lin Jia, Juan Li, Hongwei Yu, Yueke Zhu, Jinling Dong, Qinghua Meng

    Doi: 10.14218/JCTH.2021.00202

    Original Article

    Hepatitis B Virus Induces Microtubule Stabilization to Promote Productive Infection through Upregulating Microtubule-associated Protein 1S

    Yuanyue Guan, Bin Sun, Shijie Zhang, Yuan Zhuang, Yanxiang Huang, Minghua Lin, Rongling Zheng, Dexi Chen, Ying Shi, Yanjun Wang

    Doi: 10.14218/JCTH.2021.00090

    Original Article

    Ginsenoside Rb1 Reduces D-GalN/LPS-induced Acute Liver Injury by Regulating TLR4/NF-κB Signaling and NLRP3 Inflammasome

    Yimei Liu, Ninghua Liu, Yujing Liu, Hongyu He, Zhe Luo, Wenjun Liu, Nan Song, Minjie Ju

    Doi: 10.14218/JCTH.2021.00072

    Original Article

    Hepatotoxicity Induced by Biological Agents: Clinical Features and Current Controversies

    Nelia Hernandez, Fernando Bessone

    Doi: 10.14218/JCTH.2021.00243

    Review Article

    Tumor-associated Exosomes Are Involved in Hepatocellular Carcinoma Tumorigenesis, Diagnosis, and Treatment

    Hang Wang, Liang Yu, Peng Huang, Yongxu Zhou, Wangyang Zheng, Nanfeng Meng, Risheng He, Yi Xu, Tey Sze Keong, Yunfu Cui

    Doi: 10.14218/JCTH.2021.00425

    Review Article

    Pediatric Acute Severe Hepatitis of Unknown Origin: What is New?

    Jing Li, Wei Hu, Ji-Yuan Zhang, Fu-Sheng Wang

    Doi: 10.14218/JCTH.2022.00247

    Review Article

    Update on Sphincter of Oddi Dysfunction: A Review

    Jaimy Villavicencio Kim, George Y. Wu

    Doi: 10.14218/JCTH.2021.00167

    Review Article

    Acute Hepatitis of Unknown Origin in Children: Early Observations from the 2022 Outbreak

    Li-Ya Zhang, Li-Su Huang, Yu-Hang Yue, Rima Fawaz, Joseph K. Lim, Jian-Gao Fan

    Doi: 10.14218/JCTH.2022.00281

    Review Article

    Primary Sclerosing Cholangitis and Inflammatory Bowel Disease: A Review

    Teresa Da Cunha, Haleh Vaziri, George Y. Wu

    Doi: 10.14218/JCTH.2021.00344

    Review Article

    Statin-induced Liver Injury Patterns: A Clinical Review

    Leon D. Averbukh, Alla Turshudzhyan, David C. Wu, George Y. Wu

    Doi: 10.14218/JCTH.2021.00271

    Review Article

    Neoadjuvant and Adjuvant Therapy in Intrahepatic Cholangiocarcinoma

    Xing Chen, Jinpeng Du, Jiwei Huang, Yong Zeng, Kefei Yuan

    Doi: 10.14218/JCTH.2021.00250

    Case Report

    Imaging Findings of Hepatic Ewing’s Sarcoma on Computed Tomography and Gadobenate Dimeglumine-enhanced Magnetic Resonance Imaging: A Case Report and Literature Review

    Tao Lu, Wenhao Yang, Xingchao Liu, Xudan Yang, Chong Yang, Wenjia Di

    Doi: 10.14218/JCTH.2021.00129

    长按识别二维码

    阅读整期内容

    END

    期刊简介

    Journal of Clinical and Translational Hepatology (JCTH,《临床与转化肝脏病杂志》,pISSN: 2225-0719, eISSN: 2310-8819)是由重庆医科大学附属第二医院主办,Xia & He Publishing Inc. (华誉出版社)出版的英文学术期刊,主要收录肝病领域的临床或转化相关的研究论文、综述、述评等。

    2021 Impact Factor : 5.065

    2021 CiteScore : 6.4

    转自:华誉学术

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